What is the Purpose of this Study?
The purpose of this study is to evaluate whether pain relief can be achieved using only 1-2 radiation treatments to a painful bone lesion in patients with multiple myeloma (MM). Bone disease is common in MM patients. Radiotherapy is effective in providing some degree of pain relief from multiple myeloma related bone disease, but there is no consensus as to the most effective dose or how many treatments help lessen the pain from bone lesions. Shorter courses of radiotherapy are not only more convenient for patients and their families but interfere less with the timing of chemotherapy. Pain assessment will be conducted by asking participants about their pain level and quality of life. If patients do not achieve pain relief after only 1 or 2 treatments at 4 weeks following radiotherapy, additional radiotherapy without additional side effects could be given, with the goal of achieving pain relief.
Eligibility
- * Histologic diagnosis of multiple myeloma
- * Painful bone metastasis (index lesion) that has a radiographic correlate
- * Patient may have had any number of prior chemotherapy/immunotherapy regimens (changes to systemic therapy or use of bisphosphonates for 4 weeks before and after RT are allowed, but recording of these changes must be made so it can be accounted for)
- * Eastern Cooperative Oncology Group (ECOG) 0-2
Where can I participate?
- CS Cancer Tarzana : Amy Oppenheim
- CS Cancer at Cedars-Sinai Medical Center : Amy Oppenheim
More about this Clinical Trial
What is the full name of this clinical trial?
EIIT2023-16M-18-2: Phase II Multi-Institutional Study of Low-Dose Palliative Radiotherapy in the Treatment of Symptomatic Bone metastases from Multiple Myeloma