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119 results found

Eye and Orbit, Melanoma

IDE196 in Combination with Crizotinib in Metastatic Uveal Melanoma

The purpose of this study is to determine whether an experimental medication, IDE196 (also called darovasertib), in combination with another drug, crizotinib, is safe and effective in people who have cancer in their eye (uveal ...

Breast

Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Breast Cancer

The purpose of this study is to determine whether the addition of chemotherapy to hormonal therapy and ovarian suppression is more effective than the usual approach of hormonal therapy and ovarian suppression alone for treatment ...

Colon, Melanoma, Other Female Genital, Rectum

Astellas,1012-CL-0101,Ph1,open,metastatic solid tumors,ASP1012

Primary -To determine the safety and tolerability of ASP1012 in participants with locally advanced or metastatic solid tumors -To determine the MTD and/or candidate RP2D ofASP1012 Secondary -To evaluate the PK and virus shedding of ASP1012 -To evaluate the ADAs ...

Ovary

NRG,GY033,PhII,open-label,Darolutamide+Leuprolide Acetane+Exemestane,Ovarian Granulosa Cell tumor

Primary Objective To determine the objective response rate of darolutamide, leuprolide acetate, and exemestane in recurrent adult-type granulosa cell tumors of the ovary (AGCT). 1.2 Secondary Objectives To determine duration of response of darolutamide, leuprolide acetate, and exemestane in recurrent ...