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119 results found


Breast

Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer

This study focuses on individuals who have low-risk HER2-positive breast cancer, which is a type of breast cancer that tests positive for the human epidermal growth factor receptor 2. The purpose of the study is ...


Colon, Rectum

Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery

This study focuses on individuals who have advanced colorectal cancer that has spread up to 4 body sites. The purpose of the study is to compare the usual treatment alone to ablative local therapy (ALT) ...


Breast

Elacestrant in Various Combinations in Metastatic Breast Cancer

The purpose of this study is to determine whether an endocrine therapy drug approved by the U.S. Food and Drug Administration (FDA) called elacestrant is safe and effective when given in combination with one of ...


Breast, Melanoma, Multiple Myeloma, Other Skin

Scorpion Therapeutics, Inc, STX-478-101, 1/2, Open Label, Solid, STX-478 +/- Chemo

Primary Objective - To determine the OBD and MTD of STX-478 administered as monotherapy in participants with breast cancer expressing PI3Kα H1047X mutations or other kinase domain mutations Secondary Objectives - To characterize the overall safety ...


Breast, Esophagus, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma ...

INCA33890 in Advanced or Metastatic Solid Tumors

The purpose of this study is to determine the safest and most effective dose of an experimental drug called INCA33890 in people with selected advanced or metastatic solid tumors. INCA33890 is an immune therapy (drug ...