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119 results found


Brain and Nervous System

Carboplatin and Vincristine Versus Selumetinib in Low-Grade Glioma

This study focuses on individuals who have been diagnosed with a cancer called low-grade glioma (LGG). The purpose of the study is to determine whether an experimental drug called selumetinib is as effective as the ...


Melanoma

Melanoma Margins Trial: 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma

This study focuses on individuals who have been diagnosed with a form of skin cancer called melanoma, which develops from melanocytes (pigment cells). During surgery for melanoma, the skin cancer and a small margin of ...


Breast, Cervix, Colon, Corpus Uteri, Esophagus, Kidney, Liver, Lung, Melanoma ...

KZR-261 in Advanced Solid Malignancies

The purpose of this study is to evaluate the safety and tolerability of an investigational drug called KZR-261 when given via intravenous (IV) infusion for advanced solid tumor cancer. In Part 1 of the study, ...


Melanoma

Subcutaneous Nivolumab and Relatlimab Versus Intravenous Nivolumab and Relatlimab in Previously Untreated Metastatic or Unresectable Melanoma

This study focuses on individuals with previously untreated metastatic or unresectable melanoma (melanoma that has spread or cannot be removed with surgery). A combination of 2 drugs, nivolumab and relatlimab, will be given to participants. ...


Lung

Trastuzumab Deruxtecan in Non-Small Cell Lung Cancer

This study focuses on individuals who have unresectable, locally advanced or metastatic lung cancer with a mutation on the human epidermal growth factor receptor 2 (HER2). HER2 is a protein found on the surface of ...