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217 results found

Colon, Melanoma, Other Female Genital, Rectum

Astellas,1012-CL-0101,Ph1,open,metastatic solid tumors,ASP1012

Primary -To determine the safety and tolerability of ASP1012 in participants with locally advanced or metastatic solid tumors -To determine the MTD and/or candidate RP2D ofASP1012 Secondary -To evaluate the PK and virus shedding of ASP1012 -To evaluate the ADAs ...

Ovary

NRG,GY033,PhII,open-label,Darolutamide+Leuprolide Acetane+Exemestane,Ovarian Granulosa Cell tumor

Primary Objective To determine the objective response rate of darolutamide, leuprolide acetate, and exemestane in recurrent adult-type granulosa cell tumors of the ovary (AGCT). 1.2 Secondary Objectives To determine duration of response of darolutamide, leuprolide acetate, and exemestane in recurrent ...