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217 results found


Breast, Melanoma, Multiple Myeloma, Other Skin

Scorpion Therapeutics, Inc, STX-478-101, 1/2, Open Label, Solid, STX-478 +/- Chemo

Primary Objective - To determine the OBD and MTD of STX-478 administered as monotherapy in participants with breast cancer expressing PI3Kα H1047X mutations or other kinase domain mutations Secondary Objectives - To characterize the overall safety ...


Other

SELUTION SLR 014 Drug Eluting Balloon in the Treatment of In-Stent Restenosis

The purpose of this study is to demonstrate whether an investigational device called the SELUTION SLR drug eluting balloon is well tolerated and whether it works as effectively as other currently available treatments for patients ...


Breast, Esophagus, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma ...

INCA33890 in Advanced or Metastatic Solid Tumors

The purpose of this study is to determine the safest and most effective dose of an experimental drug called INCA33890 in people with selected advanced or metastatic solid tumors. INCA33890 is an immune therapy (drug ...


Ovary

TransCon IL-2 β/​γ in Locally Advanced or Metastatic Solid Tumor Malignancies

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called TransCon IL-2 beta/gamma when given in combination with chemotherapy or in combination with another experimental drug, TransCon TLR7/8 ...


Other Hematopoietic

Zanubrutinib in Mantle Cell Lymphoma

This study focuses on individuals who have mantle cell lymphoma, which is a type of non-Hodgkin lymphoma. Zanubrutib is a drug approved by the U.S. Food and Drug Administration (FDA) for use in mantle cell ...