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Lorundrostat in Uncontrolled Hypertension

The purpose of this study is to assess the blood pressure lowering effect of an experimental drug called lorundrostat (MLS 101) in combination with medications (that are approved by the U.S. Food and Drug Administration-FDA) ...


Breast

Shorter Anthracycline-Free Chemo Immunotherapy in Early Triple-Negative Breast Cancer

The purpose of this study is to compare the standard-of-care chemo-immunotherapy (carboplatin/paclitaxel followed by adriamycin/cyclophosphamide plus pembrolizumab, given in 6 months) treatment for early-stage, triple-negative breast cancer to a shorter non-anthracycline chemo-immunotherapy treatment (carboplatin docetaxel ...


Other

Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...


Breast, Cervix, Esophagus, Kidney, Larynx, Liver, Lung, Other Digestive Organ ...

BMS-986449 Alone and in Combination with Nivolumab in Advanced Solid Tumors

This study will evaluate the safety and side effects of an investigational drug called BMS-986449 in patients with an advanced solid tumor that has grown or come back. The study also aims to determine the ...


Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female ...

GIM-122 as a Single Agent in Advanced Solid Malignancies

The purpose of this study is to evaluate an investigational drug called GIM-122 in people who have been diagnosed with an advanced or malignant tumors. These patients have tumors that were eligible to be treated ...